What does this research mean for the field?

The medullary lateral tegmental field (LTF) acts as a crucial synaptic relay for basal sympathetic nerve discharge via non-NMDA excitatory amino acid receptors, and excitatory amino acid-mediated drive to the rostral ventrolateral medulla (RVLM) significantly contributes to basal sympathoexcitatory activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 2000AJP Regulatory Integrative and Comparative Physiology

Medullary lateral tegmental field: an important source of basal sympathetic nerve discharge in the cat

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Population

Urethan-anesthetized, baroreceptor-denervated cats

Comparison

Bilateral microinjection of NBQX or D-AP5 into… vs Control (baseline)

Design

Preclinical

Authors

SBSusan M. BarmanMichigan United GGGerard L. GebberMichigan State University HOHakan S. OrerKoç University

Discussion

Member takes

Implication

Premature for clinical translation; leaves open translational studies of LTF non-NMDA receptors in sympathetic regulation.

Structured PICO

Population

Urethan-anesthetized, baroreceptor-denervated cats

Intervention

Bilateral microinjection of NBQX (non-NMDA receptor antagonist) or D-AP5 (NMDA receptor antagonist) into the medullary lateral tegmental field (LTF) or rostral ventrolateral medulla (RVLM)

Comparator

Control (baseline)

Outcome

Inferior cardiac sympathetic nerve discharge (SND) and mean arterial pressure (MAP)surrogate

The medullary lateral tegmental field acts as an important synaptic relay for basal sympathetic nerve discharge in cats, mediated by non-NMDA excitatory amino acid receptors.

Cite This Study

Barman et al. (2000) studied this question.

synapsesocial.com/papers/6a1e860940bc8a3dd76903e2 https://doi.org/10.1152/ajpregu.2000.278.4.r995

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Medullary lateral tegmental field: an important source of basal sympathetic nerve discharge in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Medullary lateral tegmental field: an important source of basal sympathetic nerve discharge in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider