Key result
Acetylcholine inhibits the release of norepinephrine from adrenergic nerve terminals via muscarinic receptors, modulating cardiovascular sympathetic neurotransmission.
Population
Heart and blood vessel walls (cardiovascular system)
Design
Review
Authors
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Explains parasympathetic override of sympathetic drive; leaves open therapeutic targeting of prejunctional muscarinic receptors.
The inhibitory effect of acetylcholine on cardiovascular tissues is achieved both directly on muscle cells and indirectly by inhibiting sympathetic neurotransmission.
Vanhoutte et al. (1980) conducted a review in Cardiovascular physiology. Acetylcholine inhibits the release of norepinephrine from adrenergic nerve terminals via muscarinic receptors, modulating cardiovascular sympathetic neurotransmission.
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