Why the study?
Do alpha 1-adrenergic receptors regulate parasympathetic effects on the heart in an in vivo rat model?
Population
In vivo rat model prepared for electrical stimulation of the vagus nerves
Comparison
Alpha 1-selective agonist phenylephrine and… vs Alpha 2-selective agonist BHT-920 and alpha…
Design
Preclinical
Authors
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Alpha1 receptors may modulate vagal effects in rats; hypothesis-generating and leaves open human translation.
Do alpha 1-adrenergic receptors regulate parasympathetic effects on the heart in an in vivo rat model?
Alpha 1-adrenergic receptors can regulate the release of acetylcholine from cardiac parasympathetic neurons, attenuating vagally induced bradycardia.
McGrattan et al. (1987) studied this question.
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