Population
Sprague-Dawley rats, anesthetized and instrumented, with sectioned cervical vagi and administered propranolol
Comparison
Phenylephrine infusion vs Baseline and recovery
Design
Preclinical
Authors
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Phenylephrine's site-specific autonomic effects in rats warrant caution against clinical extrapolation; leaves open mechanistic translation to human parasympathetic control.
In a rat model, phenylephrine exerts contrasting effects on cardiac parasympathetic control, inhibiting bradycardia at preganglionic sites while facilitating it at the level of ganglion cells.
Pardini et al. (1991) studied this question.
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