Key result
Several muscarinic agonists inhibited atrial tension development, ventricular rate, and neuronal noradrenaline release in isolated rabbit hearts, suggesting mediation by similar muscarinic receptors.
Population
Isolated perfused rabbit hearts
Design
Preclinical
Authors
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Provides preclinical support for uniform muscarinic effects in rabbit heart; leaves open human translation and therapeutic relevance.
This preclinical study demonstrates that similar muscarinic receptors mediate the inhibition of atrial tension, ventricular rate, and neuronal noradrenaline release in the rabbit heart.
Fozard et al. (1972) studied this question. Muscarinic agonists was evaluated on Atrial tension development, ventricular rate and noradrenaline release. Several muscarinic agonists inhibited atrial tension development, ventricular rate, and neuronal noradrenaline release in isolated rabbit hearts, suggesting mediation by similar muscarinic receptors.
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