Key result
McN-A-343 enhances stimulation-evoked transmitter release at low concentrations via presynaptic facilitation and inhibits it at higher concentrations by acting as an adrenergic neurone blocking agent.
Population
Rabbit isolated pulmonary artery and aorta
Comparison
McN-A-343 at varying concentrations (10 to 3 x… vs Control and various pharmacological…
Design
Preclinical
Authors
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Hypothesis-generating for presynaptic autonomic modulation in animals; clinical relevance to human vascular transmission remains untested.
McN-A-343 exhibits a dual effect on vascular neuroeffector transmission, enhancing transmitter release at low concentrations and inhibiting it at high concentrations via non-muscarinic mechanisms.
Ove A. Nedergaard (1981) studied this question. McN-A-343 vs. Control was evaluated on Contractions evoked by electrical-field stimulation. McN-A-343 enhances stimulation-evoked transmitter release at low concentrations via presynaptic facilitation and inhibits it at higher concentrations by acting as an adrenergic neurone blocking agent.