Key result
Acetylcholine microinjection into the PPT lowers MAP and SBP without altering heart rate in rats.
Why the study?
The cardiovascular effects of muscarinic receptors in the pedunculopontine tegmental nucleus were not previously examined.
Population
Anesthetized rats
Comparison
Acetylcholine (90 and 150 nmol), atropine (3 and 9 nmol), and their combinations vs control
Design
Preclinical experimental study with drug microinjections
Authors
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Identifies PPTg cholinergic signaling as a BP-lowering site in anesthetized rats; leaves open translation to conscious or disease models.
Activation of cholinergic muscarinic receptors in the pedunculopontine tegmental nucleus has an inhibitory effect on blood pressure without significantly affecting heart rate in anesthetized rats.
Alikhani et al. (2022) studied Cardiovascular responses in anesthetized rats. Acetylcholine and Atropine microinjection into the PPT vs. Control was evaluated on Maximum change in mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR). Microinjection of acetylcholine into the pedunculopontine tegmental nucleus significantly decreased mean arterial pressure and systolic blood pressure without changing heart rate in anesthetized rats.
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