Key result
Vagal stimulation significantly decreased noradrenaline release from rabbit atria when sympathetic impulses were delayed by 3-10 ms or 200-283 ms, indicating two phases of muscarinic inhibition.
Population
Isolated perfused rabbit atria preparation with transmitter stores labelled with [14C]choline and…
Comparison
Vagal nerve stimulation preceding sympathetic… vs Expected value of [3H]noradrenaline outflow…
Design
Preclinical
Authors
Loading...
Hypothesis-generating for biphasic muscarinic control of cardiac sympathetic release; leaves open translation to intact models and human physiology.
Vagal stimulation induces a biphasic muscarinic inhibition of noradrenaline release in rabbit atria, suggesting the involvement of two separate populations of muscarinic receptors.
Habermeier-Muth et al. (1988) studied this question. Vagal stimulation vs. Expected value from sympathetic stimulation alone was evaluated on [3H]noradrenaline outflow. Vagal stimulation significantly decreased noradrenaline release from rabbit atria when sympathetic impulses were delayed by 3-10 ms or 200-283 ms, indicating two phases of muscarinic inhibition.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: