Basic fibroblast growth factor administration reduced left ventricular infarct size (1.2% vs 5.1%) and prevented pacing-induced hemodynamic deterioration in chronically ischemic porcine hearts.
Does extraluminal administration of bFGF improve myocardial function, blood flow, and reduce infarct size in a porcine model of chronic myocardial ischemia?
Periadventitial administration of bFGF in a porcine model of gradual coronary occlusion improves coronary flow, reduces infarct size, and prevents pacing-induced hemodynamic deterioration.
Absolute Event Rate: 1.2% vs 5.1%
p-value: p=<0.05
The effect of basic fibroblast growth factor (bFGF) administration on regional myocardial function and blood flow in chronically ischemic hearts was studied in 26 pigs instrumented with proximal circumflex coronary artery (LCX) ameroid constrictors. In 13 animals bFGF was administered extraluminally to the proximal left anterior descending (LAD) and LCX arteries with heparin-alginate beads and 13 other animal served as controls. bFGF-treated pigs showed a fourfold reduction in left ventricular infarct size compared to untreated controls (infarct size: 1.2 +/- 0.4% vs. 5.1 +/- 1.3% of LV mass, mean +/- SEM, P 30.5 +/- 8.5%, P 14.3 +/- 7.0%, P = NS). Furthermore, LV end-diastolic pressure rise with rapid pacing was less in bFGF-treated than control pigs (pre-pacing; pacing; post-pacing, 10 +/- 1; 17 +/- 3; 11 +/- 1* mmHg vs 10 +/- 1; 24 +/- 4; 15 +/- 1 mmHg, *P < 0.05 vs. control). Coronary blood flow in the LCX territory (normalized for LAD flow) was also better during pacing in bFGF-treated pigs than in controls. Thus, periadventitial administration of bFGF in a gradual coronary occlusion model in pigs results in improvement of coronary flow and reduction in infarct size in the compromised territory as well as in prevention of pacing-induced hemodynamic deterioration.
Harada et al. (Mon,) conducted a other in Chronic myocardial ischemia (n=26). Basic fibroblast growth factor (bFGF) vs. Control was evaluated on Left ventricular infarct size (% of LV mass) (p=<0.05). Basic fibroblast growth factor administration reduced left ventricular infarct size (1.2% vs 5.1%) and prevented pacing-induced hemodynamic deterioration in chronically ischemic porcine hearts.