Key result
Alcohol septal ablation in patients ≥ 60 years with obstructive HCM was associated with reduced life expectancy compared to the matched general population (P=0.002).
Why the study?
The long-term survival and causes of death in patients aged 60 years or older after alcohol septal ablation for obstructive hypertrophic cardiomyopathy remained unresolved.
What is the long-term survival and cause of death in patients ≥ 60 years of age after alcohol septal ablation for obstructive hypertrophic cardiomyopathy compared to the general population?
Cohort (n=156)
What is the long-term survival and cause of death in patients ≥ 60 years of age after alcohol septal ablation for obstructive hypertrophic cardiomyopathy compared to the general population?
In patients ≥ 60 years with obstructive HCM, alcohol septal ablation is safe and effective long-term, though life expectancy remains reduced compared to the general population.
Supports caution counseling older obstructive HCM patients for alcohol septal ablation; leaves open drivers of excess mortality versus matched controls.
INTRODUCTION: The outcome of patients ≥ 60 years of age after alcohol septal ablation (ASA) for obstructive hypertrophic cardiomyopathy (HCM) remains unresolved. We sought to determine the long-term survival and the causes of death in this population. MATERIAL AND METHODS: We enrolled 156 consecutive patients (69 ±6 years, 69% women, follow-up: 4.8 ±3.5 years) who underwent ASA at ≥ 60 years of age. CONCLUSIONS: Alcohol septal ablation was safe and effective in the long-term follow-up. We observed a reduced life expectancy compared to the age- and sex-matched general population. Mortality was almost equally due to cardiovascular and non-cardiovascular causes of death.
No takes yet. Share an insight, caveat, or question.
Jahnlová et al. (2019) conducted a cohort in obstructive hypertrophic cardiomyopathy (n=156). Alcohol septal ablation vs. age- and sex-matched general population was evaluated on long-term survival and causes of death (p== 0.002). Alcohol septal ablation in patients ≥ 60 years with obstructive HCM was associated with reduced life expectancy compared to the matched general population (P=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: