Key result
A lower dose of ethanol (1-2 ml) for alcohol septal ablation preserved left ventricular ejection fraction at long-term follow-up compared to standard doses (>2 ml) (79% vs 75%, p=0.03).
Why the study?
Does a lower dose of ethanol (1-2 ml) improve long-term echocardiographic and clinical outcomes compared to a higher dose (>2 ml) in patients undergoing alcohol septal ablation for obstructive hypertrophic cardiomyopathy?
Population
54 patients with obstructive hypertrophic cardiomyopathy undergoing alcohol septal ablation
Comparison
Low-dose ethanol injection during alcohol septal… vs Higher-dose ethanol injection during alcohol…
Design
RCT, Randomized into 2 groups according to the dose of injected ethanol
Follow-up
median 39 (range 6-72) months
Authors
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Lower-dose ethanol may better preserve LVEF after alcohol septal ablation; observational data leaves open the need for randomized confirmation.
RCT (n=54)
Single-blind
1:1
No
Does a lower dose of ethanol (1-2 ml) improve long-term echocardiographic and clinical outcomes compared to a higher dose (>2 ml) in patients undergoing alcohol septal ablation for obstructive hypertrophic cardiomyopathy?
Absolute Event Rate: 79% vs 75%
p-value: p=0.03
A lower dose of ethanol (1-2 ml) for alcohol septal ablation is as hemodynamically and clinically effective as higher doses, while better preserving left ventricular ejection fraction and reducing excessive septal necrosis.
Veselka et al. (2006) conducted an RCT in Obstructive hypertrophic cardiomyopathy (n=54). Ethanol (low dose) vs. Ethanol (>2 ml) was evaluated on Left ventricular ejection fraction (LVEF) at follow-up (p=0.03). A lower dose of ethanol (1-2 ml) for alcohol septal ablation preserved left ventricular ejection fraction at long-term follow-up compared to standard doses (>2 ml) (79% vs 75%, p=0.03).
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