Why the study?
Does a lower dose of alcohol reduce infarct size while maintaining comparable clinical and hemodynamic outcomes compared to standard doses in patients undergoing septal ablation for HOCM?
Population
34 patients with highly symptomatic hypertrophic obstructive cardiomyopathy receiving maximum medical therapy
Comparison
Low dose alcohol injected into target septal… vs Standard dose alcohol injected into target…
Design
RCT, 1:1 ratio
Follow-up
6 months
Key result
Low-dose alcohol (1-2 ml) for septal ablation in HOCM resulted in a lower peak CK-MB (1.9 vs 3.2 microkat/L, P<0.05) compared to standard doses, with similar clinical outcomes at 6 months.
Authors
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Supports lower-dose alcohol septal ablation in HOCM to limit infarct size; extends dosing data with RCT confirmation of similar outcomes.
RCT (n=34)
1:1
Does a lower dose of alcohol reduce infarct size while maintaining comparable clinical and hemodynamic outcomes compared to standard doses in patients undergoing septal ablation for HOCM?
Absolute Event Rate: 1.9% vs 3.2%
p-value: p=< 0.05
A lower dose of alcohol (1-2 ml) for septal ablation in HOCM reduces infarct size while providing comparable clinical and hemodynamic benefits to standard doses.
Veselka et al. (2004) conducted an RCT in symptomatic hypertrophic obstructive cardiomyopathy (HOCM) (n=34). Alcohol septal ablation vs. Standard dose (2-4 ml; mean 3.4 +/- 0.9 ml) was evaluated on Peak of CK-MB (p=< 0.05). Low-dose alcohol (1-2 ml) for septal ablation in HOCM resulted in a lower peak CK-MB (1.9 vs 3.2 microkat/L, P<0.05) compared to standard doses, with similar clinical outcomes at 6 months.