PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
May 1, 2008Heart

Acute effects of alcohol septal ablation on systolic and diastolic left ventricular function in patients with hypertrophic obstructive cardiomyopathy

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does percutaneous transluminal septal myocardial ablation (PTSMA) by alcohol injection improve acute haemodynamics and left ventricular function in patients with symptomatic hypertrophic obstructive cardiomyopathy?

Population

17 consecutive patients with symptomatic hypertrophic obstructive cardiomyopathy referred for percutaneous…

Comparison

Percutaneous transluminal septal myocardial… vs Baseline (before the procedure)

Design

Cohort

Follow-up

acutely after the procedure

Authors

PSPaul SteendijkEMEmanuele MeligaMVMarco Valgimigli

Discussion

Loading...

Member takes

Overview

Supports acute hemodynamic effects of PTSMA in symptomatic HOCM; leaves open durability and clinical outcomes in prospective trials.

Structured PICO

Does percutaneous transluminal septal myocardial ablation (PTSMA) by alcohol injection improve acute haemodynamics and left ventricular function in patients with symptomatic hypertrophic obstructive cardiomyopathy?

P
Population
17 consecutive patients with symptomatic hypertrophic obstructive cardiomyopathy (HOCM) referred for percutaneous transluminal septal myocardial ablation (PTSMA)
I
Intervention
Percutaneous transluminal septal myocardial ablation (PTSMA) by alcohol injection (multiple 0.5-ml alcohol injections, total 2.0 (0.5) ml ethanol per patient)
C
Comparator
Baseline (before the procedure)
O
Outcome
Acute changes in haemodynamics and systolic and diastolic left ventricular function assessed by online pressure-volume loopssurrogate

Alcohol septal ablation acutely reduces systolic function but promptly improves diastolic function, maintaining overall hemodynamics in patients with symptomatic HOCM.

Cite This Study

Steendijk et al. (2008) studied this question.

synapsesocial.com/papers/6a80922ecf96de1eb9c884f9https://doi.org/10.1136/hrt.2007.139535
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Percutaneous Transluminal Septal Ablation in Hypertrophic Obstructive Cardiomyopathy1999 · 76 citations
  2. 2Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: Lower alcohol dose reduces size of infarction and has comparable hemodynamic and clinical outcome2004 · 50 citations
  3. 3Echo-guided percutaneous septal ablation for symptomatic hypertrophic obstructive cardiomyopathy: 7 years of experience2004 · 152 citations
  4. 4Septal ablation in hypertrophic obstructive cardiomyopathy improves systolic myocardial function in the lateral (free) wall: a follow-up study using CMR tissue tagging and 3D strain analysis2006 · 54 citations
  5. 5Effects of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy on Doppler Tei Index: A Midterm Follow‐Up2005 · 17 citations