What question did this study set out to answer?

This research aims to quantify the persistent suppression of bacterial growth after exposure to various antimicrobial agents.

January 1, 1981Clinical Infectious Diseases

Postantibiotic Suppression of Bacterial Growth

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Authors

RBR. W. BundtzenUniversity of Wisconsin–Madison AGAndreas GerberUniversity of Applied Sciences Biberach DCDavid L. CohnAmsterdam University College

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Implication

Randomized trial investigates postantibiotic effects on bacterial growth in gram-positive and gram-negative bacteria, revealing implications for antibiotic use.

Key Points

This research aims to quantify the persistent suppression of bacterial growth after exposure to various antimicrobial agents.
Quantitated colony-forming units after drug removal via washing, dilution, or inactivation with penicillinase.
Studied effects of beta-lactam antibiotics at varying concentrations and durations of exposure.
Evaluated persistent effects in 90% human serum.
Postantibiotic effects were observed with all drugs studied, with duration lasting 1-3 hours for gram-positive bacteria.
Higher concentrations of antibiotics were needed for gram-negative bacteria to show postantibiotic effects.
Inhibitors of protein and RNA synthesis showed the longest suppression of growth across both gram-positive and gram-negative bacteria.

Cite This Study

Bundtzen et al. (1981) studied this question.

synapsesocial.com/papers/6a64d1fcde3cbd50a6094044 https://doi.org/10.1093/clinids/3.1.28

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Implication

Randomized trial investigates postantibiotic effects on bacterial growth in gram-positive and gram-negative bacteria, revealing implications for antibiotic use.

Postantibiotic Suppression of Bacterial Growth

Discussion

Member takes

Implication

Key Points

Cite This Study

Postantibiotic Suppression of Bacterial Growth

Discussion

Member takes

Implication

Key Points

Cite This Study

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