Key result
From 2008 to 2013, 400,264 cases of HFMD were reported in Henan, China, with an annual average incidence of 70.87 per 100,000, predominantly affecting children under 5 years old and primarily caused by EV71.
Observational (n=400,264)
Yes
HFMD in Henan is primarily caused by EV71 and CA16, with children under five most affected, supporting the need for EV71 vaccination.
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May support EV71 vaccination prioritization in young children in endemic regions; extends surveillance data but leaves causal impact open.
Huang et al. (2015) conducted an observational in Hand, foot, and mouth disease (HFMD) (n=400,264). Enterovirus infection (EV71, CA16) was evaluated on Incidence and etiological characteristics of HFMD. From 2008 to 2013, 400,264 cases of HFMD were reported in Henan, China, with an annual average incidence of 70.87 per 100,000, predominantly affecting children under 5 years old and primarily caused by EV71.
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