Key result
Laser scanning confocal microscopy revealed that arteries from hypertensive rats had reduced lumen, altered cell density, increased medial volume, and smaller endothelial cell nuclei.
Population
Mesenteric resistance arteries from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats
Comparison
Laser scanning confocal microscopy with nuclear… vs Wire myography and perfusion myography
Design
Preclinical
Authors
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LSCM quantifies novel cellular remodeling in hypertensive arteries; leaves open translation to human disease mechanisms.
Laser scanning confocal microscopy is a reliable method for studying intact vessel morphology, revealing novel cellular changes in hypertensive vascular remodeling.
Arribas et al. (1997) studied Hypertension. Laser scanning confocal microscopy (LSCM) vs. Wire myography and perfusion myography was evaluated on Morphology of mesenteric resistance arteries. Laser scanning confocal microscopy revealed that arteries from hypertensive rats had reduced lumen, altered cell density, increased medial volume, and smaller endothelial cell nuclei.
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