Key result
L-NAME-induced hypertension in rats was associated with a higher incidence of low-K+-induced sustained ventricular fibrillation compared to normotensive controls (83% vs. 33%, P < 0.05).
Population
Isolated hearts from rats with hypertension induced by the nitric oxide synthase inhibitor L-NAME, and…
Comparison
Perfusion with a K-deficient solution vs Age-matched normotensive control rat hearts…
Design
Preclinical
Authors
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Hypokalemia may heighten arrhythmic risk in hypertension; leaves open connexin-43 modulation as a therapeutic target.
Absolute Event Rate: 83% vs 33%
p-value: p=< 0.05
Nitric oxide-deficient hypertension in rats is associated with decreased myocardial coupling and increased susceptibility to hypokalaemia-induced lethal arrhythmias.
Tribulová et al. (2002) studied Hypertension. L-NAME-induced hypertension vs. Normotensive controls was evaluated on Incidence of low-K+-induced sustained ventricular fibrillation (SVF) (p=< 0.05). L-NAME-induced hypertension in rats was associated with a higher incidence of low-K+-induced sustained ventricular fibrillation compared to normotensive controls (83% vs. 33%, P < 0.05).
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