Key result
The eNOS 894G allele was associated with a higher Gensini score for coronary heart disease severity (P=.020), but the studied polymorphisms were not associated with an increased risk of MI.
Why the study?
Are eNOS gene polymorphisms (-786T/C, G10T, and 894 G/T) associated with an increased risk of myocardial infarction or severity of coronary heart disease in patients younger than 45 years?
Case-Control
Are eNOS gene polymorphisms (-786T/C, G10T, and 894 G/T) associated with an increased risk of myocardial infarction or severity of coronary heart disease in patients younger than 45 years?
p-value: p=.020
The eNOS 894G allele is associated with more advanced atherosclerotic plaque burden at the time of first MI in young patients, suggesting wild-type genotypes may provide better compensatory mechanisms.
INTRODUCTION: Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a potent vasodilator. Several polymorphisms in the eNOS gene have been described, some of them being linked with the increased risk of cardiovascular disease, coronary heart disease (CHD), and coronary spasm. METHODS AND RESULTS: We studied 3 polymorphisms within the gene of eNOS (-786T/C, G10T, and 894 G/T) in patients with their first myocardial infarction (MI) younger than 45 years and in healthy volunteers. We found the relation between the occurrence of eNOS 894G allele and the Gensini score, which describes the severity of CHD (P = .020). CONCLUSIONS: The fact that first clinical manifestation of MI occurred in G carriers when the atherosclerotic plaque was much more advanced than in T carriers may suggest that wild-type genotype provided a better compensatory mechanisms due to NO synthesis and/or release. The polymorphisms within eNOS gene G10T, 894G/T, and -786T/C were not associated with the increased risk of MI.
No takes yet. Share an insight, caveat, or question.
Gluba-Brzózka et al. (2009) conducted a case-control in Myocardial Infarction. eNOS gene polymorphisms (-786T/C, G10T, and 894 G/T) vs. Wild-type genotype / healthy volunteers was evaluated on Risk of MI and Gensini score (p=.020). The eNOS 894G allele was associated with a higher Gensini score for coronary heart disease severity (P=.020), but the studied polymorphisms were not associated with an increased risk of MI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: