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April 1, 1999European Journal of Clinical Investigation

Polymorphisms of the endothelial nitric oxide synthase gene — no consistent association with myocardial infarction in the ECTIM study

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Why the study?

Are endothelial NO synthase gene (ecNOS) polymorphisms associated with myocardial infarction?

Population

531 patients with myocardial infarction and 610 control subjects recruited in France and Northern Ireland

Comparison

Endothelial NO synthase gene (ecNOS) polymorphisms vs Control subjects without myocardial infarction /…

Design

Case-control

Authors

MMaoMMalletNNicaud

Discussion

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Overview

ecNOS Glu-298 variant associates with MI only in France, not Northern Ireland; leaves open consistent genetic contribution across populations.

Structured PICO

Are endothelial NO synthase gene (ecNOS) polymorphisms associated with myocardial infarction?

P
Population
531 patients with myocardial infarction and 610 control subjects recruited in France and Northern Ireland (ECTIM study)
I
Intervention
Endothelial NO synthase gene (ecNOS) polymorphisms
C
Comparator
Control subjects without myocardial infarction / absence of specific polymorphisms
O
Outcome
Myocardial infarctionhard clinical

Endothelial nitric oxide synthase gene (ecNOS) polymorphisms do not show a consistent association with myocardial infarction across different populations.

Cite This Study

Mao et al. (1999) studied this question.

synapsesocial.com/papers/6a7e65d8b44705ee46856c49https://doi.org/10.1046/j.1365-2362.1999.00451.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction1998 · 355 citations
  2. 2Endothelial Nitric Oxide Synthase Exon 7 Polymorphism, Ischemic Cerebrovascular Disease, and Carotid Atheroma1998 · 149 citations
  3. 3Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension1995 · 161 citations
  4. 4Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene1993 · 878 citations
  5. 5Functional Analysis of the Human Endothelial Nitric Oxide Synthase Promoter1995 · 226 citations