Key result
The TropT test and CARDIAC STATus test demonstrated high cumulative sensitivity (94% vs. 97%) and negative predictive value (97% vs. 98%) for detecting acute myocardial infarction at 6 hours.
Why the study?
Do rapid bedside assays for cardiac troponin T and CK-MB/myoglobin accurately rule in or rule out acute myocardial infarction in patients with acute chest pain?
Observational (n=92)
Do rapid bedside assays for cardiac troponin T and CK-MB/myoglobin accurately rule in or rule out acute myocardial infarction in patients with acute chest pain?
Absolute Event Rate: 94% vs 97%
Rapid bedside assays for troponin T and CK-MB/myoglobin provide high sensitivity and negative predictive value for the early diagnosis of acute myocardial infarction.
Bedside troponin and CK-MB/myoglobin assays show comparable 6-hour sensitivity; hypothesis-generating for rapid AMI triage, requiring prospective validation before practice change.
The objective of this study was to determine whether two novel rapid bedside assays for whole-blood detection of cardiac troponin T and creatine kinase (CK)-MB mass/myoglobin could rule out or rule in acute myocardial infarction in patients with acute chest pain. Ninety-two patients with chest pain <12 h prior to admission were investigated. No difference in the cumulative sensitivity of the TropT test and the CARDIAC STATus test (CK-MB mass and myoglobin in combination) was found 6 h after admission (94 vs. 97%). The cumulative positive predictive value of the TropT test and CARDIAC STATus test 6 h after admission was 97 and 76%, respectively. The negative predictive value was 97% for the TropT test and 98% for the CARDIAC STATus test at this time point. Our data show that the rapid assays provide diagnostic as well as prognostic information shortly after admission.
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Lüscher et al. (1998) conducted an observational in Acute myocardial infarction (n=92). TropT test vs. CARDIAC STATus test was evaluated on Cumulative sensitivity 6 h after admission. The TropT test and CARDIAC STATus test demonstrated high cumulative sensitivity (94% vs. 97%) and negative predictive value (97% vs. 98%) for detecting acute myocardial infarction at 6 hours.
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