What question did this study set out to answer?

To evaluate how exercise training affects insulin action and pancreatic B-cell function in older adults.

June 1, 1990AJP Endocrinology and Metabolism

Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging

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To evaluate how exercise training affects insulin action and pancreatic B-cell function in older adults.
Study involved 13 healthy older men aged 61-82 years.
Participants underwent 6 months of intensive endurance exercise training.
Insulin sensitivity assessed using Bergman's minimal model; B-cell function evaluated by glucose responses.
18% increase in VO2max (from 38.2 to 45.0 ml.kg fat-free mass-1.min-1, P<0.001).
36% increase in insulin sensitivity (from 3.47 to 4.71 x 10(-5) min-1/pM, P=0.01).
B-cell function declined, evidenced by decreased acute insulin responses (AIRGlc from 351 to 245 pM, P<0.01).

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Implication

Randomized trial evaluates exercise's effects on insulin and glucose metrics in older men, indicating improved sensitivity but decreased B-cell function.

Cite This Study

Kahn et al. (1990) studied this question.

synapsesocial.com/papers/6a64e57cca348e561ba88dfb https://doi.org/10.1152/ajpendo.1990.258.6.e937

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Implication

Randomized trial evaluates exercise's effects on insulin and glucose metrics in older men, indicating improved sensitivity but decreased B-cell function.

Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging

Key Points

Discussion

Implication

Cite This Study

Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging

Key Points

Discussion

Implication

Cite This Study

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