Key result
In a reference population of 70 adults, men had higher mean PAI levels than women (5.0 vs. 2.5 kU/L), and a single 650 mg dose of aspirin did not alter PAI or t-PA activities.
Why the study?
Does a single dose of aspirin alter t-PA or PAI-1 activities, and how do age and gender influence these levels in a reference population?
Population
70 individuals (35 men, 35 women) between the ages of 20 and 65 years serving as a reference population
Comparison
Single dose of aspirin (650 mg) vs Baseline (prior to aspirin ingestion)
Design
Cross-sectional
Authors
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Provides reference ranges for t-PA/PAI-1; leaves open their clinical or prognostic utility in thrombosis risk.
Cross-Sectional (n=70)
Does a single dose of aspirin alter t-PA or PAI-1 activities, and how do age and gender influence these levels in a reference population?
Age and sex significantly influence baseline t-PA and PAI-1 levels, which must be considered when establishing reference populations for fibrinolysis studies, whereas a single dose of aspirin does not.
Krishnamurti et al. (1988) conducted a cross-sectional in Reference population (n=70). Age, gender, and aspirin ingestion was evaluated on Plasma levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities. In a reference population of 70 adults, men had higher mean PAI levels than women (5.0 vs. 2.5 kU/L), and a single 650 mg dose of aspirin did not alter PAI or t-PA activities.
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