Why the study?
What are the mechanisms responsible for impaired t-PA-mediated fibrinolysis in patients with ischaemic heart disease?
Population
45 survivors of acute myocardial infarction, examined 8 weeks after discharge from hospital
Comparison
Intravenous infusion of 1-desamino-8-D-arginine… vs Patients with preinfusion levels of active t-PA…
Design
Cohort
Follow-up
8 weeks after discharge
Authors
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Hypothesis-generating for PAI-1 as mediator of impaired fibrinolysis post-MI; prospective trials needed before therapeutic targeting.
What are the mechanisms responsible for impaired t-PA-mediated fibrinolysis in patients with ischaemic heart disease?
In survivors of acute myocardial infarction, high plasma levels of PAI-1 appear responsible for impaired t-PA-mediated fibrinolysis, and diuretic use may unfavorably affect this system.
Pedersen et al. (1994) studied this question.
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