January 1, 1991Thrombosis and Haemostasis
Correlation between Baseline Plasminogen Activator Inhibitor Levels and Clinical Outcome during Therapy with Tissue Plasminogen Activator for Acute Myocardial Infarction
Why the study?
Do baseline plasminogen activator inhibitor (PAI) levels correlate with reperfusion success and clinical outcomes in patients receiving rt-PA for acute myocardial infarction?
Population
Patients with acute myocardial infarction receiving thrombolysis with recombinant tissue plasminogen…
Design
Cohort
Follow-up
2.0 +/- 0.4 years
Authors
Discussion
Loading...
Member takes
Implication
PAI-1 levels should not guide rt-PA decisions in AMI; leaves open whether targeted inhibition improves early reperfusion.
Structured PICO
Do baseline plasminogen activator inhibitor (PAI) levels correlate with reperfusion success and clinical outcomes in patients receiving rt-PA for acute myocardial infarction?
P
Population
Patients with acute myocardial infarction receiving thrombolysis with recombinant tissue plasminogen activator (rt-PA) during the Thrombolysis and Myocardial Infarction (TAMI)-I study.
I
Intervention
Baseline plasminogen activator inhibitor (PAI) levels (exposure)
O
Outcome
Patency at the 90 min angiogramsurrogate
High baseline plasma PAI-1 levels may be detrimental to early reperfusion with t-PA in acute myocardial infarction, but do not appear to influence long-term clinical outcomes.
Cite This Study
Sane et al. (1991) studied this question.