Key result
The trans-myocardial gradient of PAI-1 6 months after MI was inversely correlated with the coronary blood flow response to acetylcholine (r = -0.43) and left ventricular regional motion (r = -0.38).
Population
28 patients with a first acute myocardial infarction due to occlusion of a proximal segment of the left…
Design
Cohort, Measurements of coronary blood flow and left ventriculograms were…
Follow-up
6 months
Authors
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May signal ongoing endothelial and LV regional dysfunction post-MI; leaves open whether PAI-1 inhibition alters outcomes.
Observational (n=28)
No
Effect estimate: r = -0.43
p-value: p=0.02
Myocardial production of PAI-1 in the infarcted lesion is associated with progressive coronary endothelial and left ventricular regional dysfunction in survivors of acute myocardial infarction.
Shimizu et al. (2015) conducted an observational in Acute Myocardial Infarction (n=28). Trans-myocardial gradient of PAI-1 was evaluated on Correlation between trans-myocardial gradient of PAI-1 and coronary blood flow response to acetylcholine 6 months after MI (r = -0.43, p=0.02). The trans-myocardial gradient of PAI-1 6 months after MI was inversely correlated with the coronary blood flow response to acetylcholine (r = -0.43) and left ventricular regional motion (r = -0.38).
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