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January 1, 2002Pathophysiology of Haemostasis and Thrombosis

Plasma Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Levels in Acute Myocardial Infarction

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Population

42 patients diagnosed with acute myocardial infarction (AMI)

Design

Cohort

Authors

AGApar Kishor GantiNebraska Medical CenterAPAnil PottiDuke Medical CenterRYRadha YegnanarayanB. J. Medical College & Sassoon Hospital

Discussion

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Implication

Admission t-PA/PAI-1 levels should not yet change AMI practice; leaves open their added prognostic value in prospective cohorts.

Structured PICO

P
Population
42 patients diagnosed with acute myocardial infarction (AMI)
O
Outcome
Levels of endogenous tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in platelet-poor plasma on admissionsurrogate

In patients with acute myocardial infarction, admission levels of t-PA and PAI-1 vary significantly based on hypertension status, infarct site, and survival outcome.

Cite This Study

Ganti et al. (2002) studied this question.

synapsesocial.com/papers/6a210341fd1130a429f64d9fhttps://doi.org/10.1159/000065080

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Release of Platelet Plasminogen Activator Inhibitor 1 in Whole Blood Is Increased in Patients With Type II Diabetes1995 · 38 citations
  2. 2Tissue plasminogen activator and other risk factors as predictors of cardiovascular events in patients with severe angina pectoris1991 · 174 citations
  3. 3Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction1985 · 1,895 citations
  4. 4Association of Fibrinolytic Parameters With Early Atherosclerosis1995 · 290 citations
  5. 5Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay1988 · 530 citations