Key result
rt-PA yields lower PAI-1 levels than streptokinase, promoting better infarct-related artery patency.
Why the study?
The relationship between PAI-1 levels after thrombolytic therapy with rt-PA versus streptokinase and infarct-related artery patency in acute myocardial infarction was unclear.
Does rt-PA compared to streptokinase affect PAI-1 levels and vessel patency in patients with acute myocardial infarction?
RCT (n=65)
randomized
Does rt-PA compared to streptokinase affect PAI-1 levels and vessel patency in patients with acute myocardial infarction?
p-value: p=<0.01
Thrombolytic therapy with streptokinase induces a more pronounced increase in PAI-1 levels compared to rt-PA, which correlates with poorer infarct-related artery patency.
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Post-thrombolysis PAI-1 rise may link to poorer patency after SK; leaves open whether PAI-1 quenching improves thrombolytic success in AMI.
Paganelli et al. (1999) conducted an RCT in acute myocardial infarction (n=65). rt-PA vs. Streptokinase was evaluated on Area under the PAI-1 curve (p=<0.01). Thrombolytic therapy with streptokinase resulted in a significantly higher area under the PAI-1 curve compared to rt-PA (p<0.01), which correlated with poor infarct-related artery patency.
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