Why the study?
Does thrombolytic therapy alter fibrinolytic system components (t-PA, PAI-1, D-dimer) in patients with acute myocardial infarction?
Population
57 consecutive patients with acute myocardial infarction and 25 normal subjects.
Comparison
Thrombolytic therapy with 100 mg rt-PA or 1.5 MU… vs 10 AMI patients not treated with thrombolytic…
Design
Cohort
Follow-up
24 hours
Authors
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Fibrinolytic marker rises after thrombolysis in AMI may reflect larger infarcts; leaves open whether monitoring t-PA or PAI-1 improves outcomes.
Does thrombolytic therapy alter fibrinolytic system components (t-PA, PAI-1, D-dimer) in patients with acute myocardial infarction?
Thrombolytic therapy in AMI significantly increases fibrinolytic components like t-PA and PAI-1, which correlate with infarct size.
IOANNIDOU-PAPAYANNAKI et al. (2000) studied this question.
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