Plasma sodium - ignored and underestimated

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Hypertension and type 2 diabetes mellitus (n=265). Intervention: A/B vs. E 10 mg uptitrated to 20 mg. Primary outcome: Time to goal BP (p=0.0115).

Fei He

doi:10.1016/j.amjhyper.2004.03.478

May 1, 2004American Journal of HypertensionOpen Access

Plasma sodium - ignored and underestimated

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Why the study?

Does initial fixed-dose combination therapy with A/B reduce time to goal BP compared with E monotherapy in African Americans with hypertension and type 2 diabetes mellitus?

Study Design

Type

RCT (n=265)

Blinding

Double-blind

Randomization

randomized

Multicenter

Yes

Structured PICO

Does initial fixed-dose combination therapy with A/B reduce time to goal BP compared with E monotherapy in African Americans with hypertension and type 2 diabetes mellitus?

P

Population

265 African American patients aged 18-80 years with hypertension and type 2 diabetes mellitus, followed for 24 weeks.

I

Intervention

A/B (fixed-dose combination) 5/10 mg uptitrated to 5/20 mg after 4 weeks if BP >130/80 mm Hg, with addition of hydrochlorothiazide (HCTZ) 12.5 mg at week 8 if goal not achieved.

C

Comparator

E (monotherapy) 10 mg uptitrated to 20 mg after 4 weeks if BP >130/80 mm Hg, with addition of hydrochlorothiazide (HCTZ) 12.5 mg at week 8 if goal not achieved.

O

Outcome

Time to goal BPsurrogate

Main Result

Absolute Event Rate: 10.1% vs 10.5%

p-value: p=0.0115

Ask about this paper

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Implication

Initial fixed-dose combination therapy with A/B achieved more rapid and substantial reductions in BP compared with E monotherapy in African Americans with hypertension and type 2 diabetes.

Abstract

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Discussion

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Cite This Study

Fei He (2004) conducted an RCT in Hypertension and type 2 diabetes mellitus (n=265). A/B vs. E 10 mg uptitrated to 20 mg was evaluated on Time to goal BP (p=0.0115).

synapsesocial.com/papers/6a64e5f81fe8a3b7faf699d5 https://doi.org/10.1016/j.amjhyper.2004.03.478

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Plasma sodium - ignored and underestimated

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Plasma sodium - ignored and underestimated

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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