Key result
Calmodulin modulates muscle excitation-contraction coupling by interacting with both ryanodine receptors and dihydropyridine receptors in a calcium-dependent manner.
This review highlights the complex role of calmodulin in modulating RyR1 and L-type calcium channels during skeletal muscle excitation-contraction coupling.
Bi-directional DHPR-RyR coupling refines Ca2+ signaling in muscle; extends mechanistic models but leaves clinical translation open.
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Wei Tang (2002) conducted a review in Muscle excitation-contraction coupling. Calmodulin was evaluated. Calmodulin modulates muscle excitation-contraction coupling by interacting with both ryanodine receptors and dihydropyridine receptors in a calcium-dependent manner.
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