Population
Skeletal muscle Ca2+ release channel and synthetic peptides representing amino acids 3614-3643 and 1975-1999…
Design
Preclinical
Authors
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Calmodulin-RYR1 binding sites merit structural follow-up; leaves open functional impact on channel gating in vivo.
Calmodulin likely binds at a site of intersubunit contact on the skeletal muscle ryanodine receptor (RYR1), involving amino acids 3614-3643 on one subunit and 1975-1999 on an adjacent subunit.
Zhang et al. (2003) studied this question.
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