Key result
Repetitive stimulation of rat fast skeletal muscle increased peak twitch tension up to 1.9 times the control value, with changes in twitch time course dependent on stimulus number and frequency.
Why the study?
Does repetitive stimulation alter the isometric twitch contraction in rat fast skeletal muscle?
Population
Rat extensor digitorum longus muscle in vitro (35 degrees C)
Comparison
Repetitive stimulation at 20 c/s and 300 c/s vs Control value (baseline twitch)
Design
Preclinical
Authors
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In vitro rat muscle data leave open human translation; extends mechanistic understanding of twitch potentiation.
Does repetitive stimulation alter the isometric twitch contraction in rat fast skeletal muscle?
Repetitive stimulation of rat fast skeletal muscle induces post-tetanic potentiation of peak twitch tension up to 1.9 times the control value, with time course changes dependent on stimulation frequency and duration.
Close et al. (1968) studied this question. Repetitive stimulation vs. Control value was evaluated on Peak tension and time course of isometric twitch contractions. Repetitive stimulation of rat fast skeletal muscle increased peak twitch tension up to 1.9 times the control value, with changes in twitch time course dependent on stimulus number and frequency.
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