Key result
High serum IGFBP7 levels (≥35.80 ng/ml) were associated with a significantly increased risk of metabolic syndrome (OR 2.758) compared to low levels.
Why the study?
Are serum IGFBP7 levels associated with insulin resistance and metabolic syndrome in a Chinese population?
Population
Chinese population with metabolic syndrome and insulin resistance compared to healthy control subjects
Comparison
High serum IGFBP7 levels vs Healthy control subjects
Design
Case-control
Authors
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Serum IGFBP7 was associated with IR and MetS; hypothesis-generating and requires prospective validation before any clinical role.
Case-Control (n=2,625)
No
Are serum IGFBP7 levels associated with insulin resistance and metabolic syndrome in a Chinese population?
Odds Ratio: 2.758 (95% CI 2.308–3.297)
p-value: p=<0.001
Higher serum IGFBP7 levels are associated with an increased risk of insulin resistance and metabolic syndrome in a Chinese population, suggesting it may be a potential interventional target.
Liu et al. (2015) conducted a case-control in Metabolic syndrome and insulin resistance (n=2,625). High serum IGFBP7 levels (≥35.80 ng/ml) vs. Low serum IGFBP7 levels (<35.80 ng/ml) was evaluated on Risk of metabolic syndrome (OR 2.758, 95% CI 2.308-3.297, p=<0.001). High serum IGFBP7 levels (≥35.80 ng/ml) were associated with a significantly increased risk of metabolic syndrome (OR 2.758) compared to low levels.
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