Why the study?
Can left vagus nerve stimulation be utilized in a closed-loop bioelectronic system to treat resistant hypertension?
Can left vagus nerve stimulation be utilized in a closed-loop bioelectronic system to treat resistant hypertension?
Left vagus nerve stimulation offers a theoretical basis for a closed-loop bioelectronic system to treat resistant hypertension by modulating aortic baroreceptor signals.
LVN aortic baroreceptor stimulation and recording may enable novel bioelectronic hypertension therapy; leaves open clinical validation.
Present bioelectronic devices for the treatment of resistant hypertension are based on electric stimulation of the carotid baroreceptors. Left vagus nerve (LVN) stimulation, to modulate the aortic baroreceptor signals has received less attention. Undeservedly so, since the aortic baroreceptors have a central role in the blood pressure (BP) control. Moreover, from the same site at the LVN where the stimulation is applied, a nerve signal can be recorded as well. This nerve signal mimics the BP in the aortic arch and mirrors the respiratory activity. As such, this signal could be used in a closed-loop LVN stimulation system to monitor the BP and physical activity as needed for safety and efficacy of any BP control system.
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Sevcencu et al. (2018) conducted a review in resistant hypertension. Left vagus nerve (LVN) stimulation was evaluated.
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