Key result
Smoking, assessed by serum cotinine positivity, was significantly more prevalent in patients with abdominal aortic aneurysm compared to controls (34.2% vs 19.3%, P=0.001).
Why the study?
Is smoking associated with an increased prevalence of abdominal aortic aneurysm?
Case-Control (n=404)
Is smoking associated with an increased prevalence of abdominal aortic aneurysm?
Absolute Event Rate: 34.2% vs 19.3%
p-value: p=.001
Smoking and ischemic heart disease are significant predictors of abdominal aortic aneurysm prevalence, reinforcing the need for smoking cessation and risk factor modification.
Cotinine-positive smoking was associated with AAA; leaves open whether biochemical confirmation refines risk stratification or management thresholds.
Abdominal aortic aneurysm is common. The aim of this study was to assess the effect of smoking on prevalence and management. Patients attending the vascular unit and appropriate controls were prospectively recruited. A smoking history revealed tobacco exposure in pack years. Serum cotinine was assessed biochemically. Independent risk factors were statistically determined. In all, 202 (186 men) patients were recruited, with 202 (197 men) controls. A total of 69 patients tested positive for cotinine, whereas 39 controls were positive (P = .001). Smoking and ischemic heart disease were significant predictors for aneurysm prevalence. Cardiac disease emerged as a more important predictor than smoking in symptomatic patients. In noncardiac patients, smoking and hypercholesterolemia were significant risk factors. Smoking is a significant predictor for aneurysm development. In high-risk patients, the cardiac disease process is the most important factor, with control of this imperative. However, in noncardiac patients, smoking cessation and lipid-lowering therapy are crucial.
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Badger et al. (2008) conducted a case-control in Abdominal aortic aneurysm (n=404). Smoking vs. Non-smokers was evaluated on Serum cotinine positivity (p=.001). Smoking, assessed by serum cotinine positivity, was significantly more prevalent in patients with abdominal aortic aneurysm compared to controls (34.2% vs 19.3%, P=0.001).
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