Key result
Lowering the pH of the reperfusion media to 6.4 during the initial 3 minutes of reperfusion markedly reduced lactate dehydrogenase release and infarct size (P<0.001).
Population
Isolated rat hearts submitted to 40 min of ischaemia and 30 min of reperfusion, and isolated myocytes
Comparison
Lowering pH of the reperfusion media to 6.4… vs Reperfusion at higher pH (up to 7.0)
Design
Preclinical
Follow-up
30 min of reperfusion
Authors
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Acidic reperfusion effects on pHi and cell death in rat hearts remain preliminary; leaves open any role in clinical myocardial salvage.
p-value: p=<0.001
A brief 3-minute period of acidic reperfusion enhances myocardial salvage by delaying intracellular pH normalization, whereas prolonged acidic reperfusion is detrimental.
INSERTE et al. (2007) studied Reperfusion injury. Acidic reperfusion vs. pH 7.0 or extended acidic reperfusion was evaluated on Lactate dehydrogenase release and infarct size (p=<0.001). Lowering the pH of the reperfusion media to 6.4 during the initial 3 minutes of reperfusion markedly reduced lactate dehydrogenase release and infarct size (P<0.001).
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