Key result
Pre-treatment with propranolol improved ischaemia/reperfusion-induced contractile dysfunction and protected mitochondrial function in isolated rat hearts, likely by attenuating sodium influx.
Population
Isolated perfused rat hearts subjected to 35-min ischaemia followed by 60-min reperfusion, and mitochondria…
Comparison
Pre-treatment with propranolol at concentrations… vs Untreated ischaemic/reperfused hearts
Design
Preclinical
Follow-up
35-min ischaemia followed by 60-min reperfusion
Authors
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Hypothesis-generating for propranolol in myocardial ischaemia/reperfusion; prospective in vivo and clinical studies required before any practice consideration.
Propranolol protects against ischemia/reperfusion injury in rat hearts by attenuating sodium influx and preserving mitochondrial function.
Iwai et al. (2002) studied Ischaemic/reperfused heart. Propranolol vs. Control (ischaemia/reperfusion without propranolol) was evaluated on Contractile dysfunction, creatine kinase release, and mitochondrial oxygen consumption rate. Pre-treatment with propranolol improved ischaemia/reperfusion-induced contractile dysfunction and protected mitochondrial function in isolated rat hearts, likely by attenuating sodium influx.
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