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October 31, 2014Journal of the National Comprehensive Cancer NetworkOpen Access

Approach to the Management of Incidental Venous Thromboembolic Events in Patients With Cancer

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Key result

Incidental venous thromboembolism in cancer patients carries similar prognostic implications to symptomatic events, and current evidence supports the use of standard anticoagulation for its management.

Why the study?

Does standard anticoagulation improve outcomes in patients with cancer and incidental venous thromboembolism?

Population

Patients with cancer and incidentally discovered venous thromboembolic events (VTE)

Design

Review

Authors

COCasey L. O’ConnellUniversity of Southern CaliforniaHLHoward A. LiebmanUniversity of Southern California

Discussion

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Implication

Suggests incidental cancer-associated VTE may merit anticoagulation; leaves open need for randomized confirmation before practice change.

Structured PICO

Does standard anticoagulation improve outcomes in patients with cancer and incidental venous thromboembolism?

P
Population
Patients with cancer and incidentally discovered venous thromboembolic events (VTE)
I
Intervention
Standard anticoagulation

Incidental VTE in cancer patients should generally be treated with standard anticoagulation, similar to the management of symptomatic events.

Limitations

  • Lack of prospective clinical trial data specifically evaluating treatments for incidental VTE in cancer patients
  • Reliance on retrospective and case-controlled reports
  • Past clinical trials have not consistently distinguished between incidental and symptomatic VTE

Cite This Study

O’Connell et al. (2014) conducted a review in Incidental venous thromboembolism (VTE) in cancer patients. Standard anticoagulation was evaluated. Incidental venous thromboembolism in cancer patients carries similar prognostic implications to symptomatic events, and current evidence supports the use of standard anticoagulation for its management.

synapsesocial.com/papers/6a6504d08949150ab1cd31f5https://doi.org/10.6004/jnccn.2014.0155

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unsuspected Pulmonary Emboli in Cancer Patients: Clinical Correlates and Relevance2006 · 148 citations
  2. 2Clinicians' Response to Radiologists' Reports of Isolated Subsegmental Pulmonary Embolism or Inconclusive Interpretation of Pulmonary Embolism Using MDCT2005 · 177 citations
  3. 3Risk of Recurrent Venous Thromboembolism and Mortality in Patients With Cancer Incidentally Diagnosed With Pulmonary Embolism: A Comparison With Symptomatic Patients2011 · 264 citations
  4. 4Symptoms Adversely Impact Survival Among Patients With Cancer and Unsuspected Pulmonary Embolism2011 · 34 citations