January 1, 1997Thrombosis and Haemostasis
Defective Interaction between von Willebrand Factor and Platelet Glycoprotein I b – A Familial Study of Peripheral Arterial Occlusive Disease
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Key result
The provided text contains only the editorial board and masthead information for the journal Thrombosis and Haemostasis, with no clinical study data.
Population
30 individuals from ten families, comprising 15 patients with symptomatic peripheral arterial occlusive…
Design
Case-control
Authors
Discussion
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Implication
These hemostatic changes in PAOD merit prospective validation; leaves open utility for risk stratification or therapy guidance.
Structured PICO
P
Population
30 individuals from ten families, comprising 15 patients with symptomatic peripheral arterial occlusive disease (PAOD) and 15 healthy siblings.
C
Comparator
15 healthy siblings
O
Outcome
Hemostatic variables and platelet function, including D-dimer and ristocetin-induced maximal platelet aggregation (RIPA)surrogate
Patients with symptomatic PAOD show increased D-dimer and reduced ristocetin-induced platelet aggregation compared to healthy siblings, which does not appear to reflect down-regulation of platelet surface glycoprotein Ib.
Cite This Study
Kauhanen et al. (1997) studied this question. The provided text contains only the editorial board and masthead information for the journal Thrombosis and Haemostasis, with no clinical study data.
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