December 1, 1993Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin.

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Population

40 patients with stable peripheral arterial occlusive disease of varying severity

Design

Cross-sectional

Authors

RLRiitta LassilaUniversity of Helsinki SPSeija PeltonenUniversity of Helsinki MLMauri LepäntaloUniversity of Helsinki

Discussion

Member takes

Implication

These cross-sectional associations are hypothesis-generating; leaves open causal role of fibrin degradation in PAOD progression.

Structured PICO

Population

40 patients with stable peripheral arterial occlusive disease of varying severity

Outcome

Association between the severity of atherosclerosis and circulating fibrinogen, fibrinopeptide A, thrombin-antithrombin III complex, and D-dimersurrogate

In patients with stable peripheral arterial occlusive disease, the severity of atherosclerosis correlates significantly with levels of fibrinogen and D-dimer, suggesting that local degradation of cross-linked fibrin is involved in disease progression.

Cite This Study

Lassila et al. (1993) studied this question.

synapsesocial.com/papers/6a6fa190f44fa9f079dd1870 https://doi.org/10.1161/01.atv.13.12.1738

View Full Paper

Ask AI

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Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider