Why the study?
Does higher plasma fibrinogen associate with increased subclinical extracoronary and coronary atherosclerosis in hypercholesterolemic men?
Population
693 hypercholesterolemic, never-treated men free of previous or current clinical symptoms of cardiovascular…
Comparison
Upper tertile of plasma fibrinogen vs Lower tertile of plasma fibrinogen
Design
Cross-sectional
Authors
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Supports fibrinogen-subclinical atherosclerosis link in hypercholesterolemia; hypothesis-generating and should not yet change practice.
Does higher plasma fibrinogen associate with increased subclinical extracoronary and coronary atherosclerosis in hypercholesterolemic men?
Elevated plasma fibrinogen is associated with subclinical atherosclerosis across multiple vascular beds in asymptomatic hypercholesterolemic men, suggesting a synergistic atherogenic effect with hyperlipidemia.
Levenson et al. (1997) studied this question.
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