Key result
High physiological epinephrine (10 nM) significantly enhanced platelet deposition to immobilized collagen at high shear rates by 32 to 85% (p < 0.02-0.05).
Why the study?
Does high physiological epinephrine augment platelet recruitment to immobilized collagen in flowing blood?
Population
Experimental model using whole blood to test interaction between platelets and immobilized collagen
Comparison
High physiological epinephrine (10 nM) vs Control (no epinephrine)
Design
Preclinical
Authors
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May promote arterial thrombosis via enhanced platelet deposition; leaves open translation from animal models to human clinical relevance.
Does high physiological epinephrine augment platelet recruitment to immobilized collagen in flowing blood?
Effect estimate: 32 to 85% increase
p-value: p=< 0.02-0.05
Epinephrine augments platelet functions dependent on vWF interaction with GP Ib and GP IIb/IIIa, suggesting a mechanism for promoting arterial thrombosis in vivo.
Mustonen et al. (1996) studied this question. Epinephrine was evaluated on Platelet deposition at high shear rate (1,600 s-1) in PPACK- or LMWH-anticoagulated blood (32 to 85% increase, p=< 0.02-0.05). High physiological epinephrine (10 nM) significantly enhanced platelet deposition to immobilized collagen at high shear rates by 32 to 85% (p < 0.02-0.05).
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