Key result
Mean maximal accumulated oxygen deficit was lower in chronic heart failure patients than in asymptomatic left ventricular dysfunction or normal controls (12.2 vs 23.7 and 24.8 mL/kg, P<0.05).
Why the study?
Is maximal accumulated oxygen deficit (MAOD) measurement feasible and repeatable in patients with chronic heart failure, and how does it compare to normal controls?
Population
20 subjects: 10 with chronic heart failure, 5 with asymptomatic left ventricular dysfunction, and 5 normal…
Comparison
Maximal accumulated oxygen deficit measurement… vs Normal controls and ALVD patients.
Design
Cross-sectional
Authors
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MAOD measurement feasible via single CPET in CHF; leaves open clinical utility pending larger validation studies.
Cross-Sectional (n=20)
Is maximal accumulated oxygen deficit (MAOD) measurement feasible and repeatable in patients with chronic heart failure, and how does it compare to normal controls?
p-value: p=< 0.05
MAOD is repeatedly measurable in CHF patients and is significantly lower than in age-matched ALVD patients and normal controls, independent of muscle mass.
Mezzani et al. (2006) conducted a cross-sectional in Chronic heart failure and asymptomatic left ventricular dysfunction (n=20). Chronic heart failure vs. Asymptomatic left ventricular dysfunction and normal controls was evaluated on Mean maximal accumulated oxygen deficit (meanMAOD) (p=< 0.05). Mean maximal accumulated oxygen deficit was lower in chronic heart failure patients than in asymptomatic left ventricular dysfunction or normal controls (12.2 vs 23.7 and 24.8 mL/kg, P<0.05).
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