Key result
Combined preoperative oral and peroperative systemic antibiotic therapy significantly reduced septic postoperative complications (3.3%) compared to oral (30%) or systemic (23%) therapy alone (P<0.05).
Why the study?
Does combined oral preoperative and systemic peroperative antibiotic therapy reduce septic postoperative complications in patients undergoing elective colorectal surgery compared to either therapy alone?
Population
90 patients requiring elective colorectal surgery
Comparison
Combination of oral preoperative antibiotic… vs Oral preoperative antibiotic therapy alone OR…
Design
RCT, Randomized
Follow-up
postoperative
Authors
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Should not yet alter prophylaxis strategies; leaves open optimal regimen selection in larger trials.
RCT (n=90)
randomized
Does combined oral preoperative and systemic peroperative antibiotic therapy reduce septic postoperative complications in patients undergoing elective colorectal surgery compared to either therapy alone?
p-value: p=<0.05
The combination of oral preoperative and systemic peroperative antibiotic therapy is more effective than either alone in preventing septic complications after colorectal surgery.
Lazorthes et al. (1982) conducted an RCT in Colorectal surgery (n=90). Combined preoperative oral and peroperative systemic antibiotic therapy vs. Preoperative oral antibiotics alone or peroperative systemic antibiotics alone was evaluated on Total number of septic postoperative complications (p=<0.05). Combined preoperative oral and peroperative systemic antibiotic therapy significantly reduced septic postoperative complications (3.3%) compared to oral (30%) or systemic (23%) therapy alone (P<0.05).
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