What is the clinical evidence from this study?

Study design: Other. Population: Arrhythmias. Intervention: Wild-type strain vs. Wistar strain. Primary outcome: Incidence of arrhythmias (ventricular premature beats) and sympathetic responsiveness during social stress.

What question did this study set out to answer?

This research aims to investigate how social stress affects arrhythmia vulnerability in rats with varying autonomic responses.

August 1, 1998AJP Heart and Circulatory Physiology

Vulnerability to arrhythmias during social stress in rats with different sympathovagal balance

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Key result

Wild-type rats exhibited a higher sympathetic tone and a much higher incidence of ventricular premature beats during social stress compared with Wistar rats.

Population

Healthy, freely moving Wistar and wild-type rats

Comparison

Social stress episode (defeat) vs Comparison between Wistar and wild-type strains

Design

Preclinical

Authors

ASAndrea SgoifoElectrophysiology SBSietse F. de BoerLeiden University BBBauke BuwaldaUniversity of Groningen

Discussion

Member takes

Implication

Social stress may promote arrhythmias via sympathetic activation in rats; leaves open translation to human arrhythmia risk.

Key Points

This research aims to investigate how social stress affects arrhythmia vulnerability in rats with varying autonomic responses.
Rats (Wistar and wild type) underwent social stress episodes while their electrocardiograms were monitored telemetrically.
Blood samples were taken to measure plasma norepinephrine levels and monitor sympathovagal balance through R-R interval variability.
Electrocardiograms assessed the occurrence of arrhythmias and sympathetic activity during stress episodes.
Wild-type rats exhibited a higher incidence of arrhythmias (ventricular premature beats) compared to Wistar rats.
Increased sympathetic tone was observed in wild-type animals, indicated by more significant changes in R-R interval and variability metrics.
Plasma norepinephrine concentrations were significantly higher in wild-type rats after sympathetic activation than in Wistar rats.

Structured PICO

Population

Healthy, freely moving Wistar and wild-type rats exposed to a social stress episode to evaluate vulnerability to arrhythmias.

Exposure

Social stress episode (defeat)

Comparator

Comparison between Wistar and wild-type strains

Outcome

Occurrence of arrhythmias (ventricular premature beats), R-R interval variability, and plasma norepinephrine concentrationssurrogate

This study establishes Wistar and wild-type rats as a valuable experimental model for investigating the cellular and electrophysiological mechanisms linking sympathovagal balance to stress-induced arrhythmias.

Cite This Study

Sgoifo et al. (1998) studied Arrhythmias. Wild-type strain vs. Wistar strain was evaluated on Incidence of arrhythmias (ventricular premature beats) and sympathetic responsiveness during social stress. Wild-type rats exhibited a higher sympathetic tone and a much higher incidence of ventricular premature beats during social stress compared with Wistar rats.

synapsesocial.com/papers/6a652a2380aad79b5c2f0413 https://doi.org/10.1152/ajpheart.1998.275.2.h460

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Vulnerability to arrhythmias during social stress in rats with different sympathovagal balance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Vulnerability to arrhythmias during social stress in rats with different sympathovagal balance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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