June 7, 2019European Heart Journal - Cardiovascular Imaging
Myocardial performance index by tissue Doppler echocardiography predicts adverse events in patients with atrial fibrillation
Key result
Increasing myocardial performance index was independently associated with a higher risk of MACE in patients with atrial fibrillation (adjusted HR 1.12; 95% CI 1.01-1.25; P=0.038).
Why the study?
The prognostic value of myocardial performance index (MPI) had not yet been assessed in patients with atrial fibrillation.
Does myocardial performance index (MPI) by tissue Doppler imaging predict major adverse cardiovascular events in patients with atrial fibrillation?
Population
210 patients with AF during examination without known HF
Comparison
Increasing MPI by tissue Doppler imaging M-mode
Design
Cohort study
Follow-up
Median 2.4 years
Authors
Discussion
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Implication
MPI may refine MACE risk stratification in AF without HF; extends MPI's independent prognostic value in echocardiography.
Study Design
Type
Cohort (n=210)
Structured PICO
Does myocardial performance index (MPI) by tissue Doppler imaging predict major adverse cardiovascular events in patients with atrial fibrillation?
P
Population
210 patients with atrial fibrillation and no known heart failure, followed for a median of 2.4 years.
E
Exposure
Myocardial performance index (MPI) measurement by tissue Doppler imaging (TDI) M-mode
O
Outcome
Combined endpoint of major adverse cardiovascular events (MACE), defined as all-cause mortality, heart failure, myocardial infarction, or strokecomposite
Main Result
Hazard Ratio: 1.2 (95% CI 1.1–1.32)
p-value: p=<0.001
Myocardial performance index obtained by TDI M-mode is an independent predictor of adverse cardiovascular events in patients with atrial fibrillation and may be useful for assessing cardiac function during ongoing arrhythmia.
Cite This Study
Dons et al. (2019) conducted a cohort in Atrial fibrillation (n=210). Myocardial performance index (MPI) by tissue Doppler imaging vs. Lower MPI was evaluated on Major adverse cardiovascular events (MACE), being all-cause mortality, heart failure, myocardial infarction, or stroke (HR 1.20, 95% CI 1.10-1.32, p=<0.001). Increasing myocardial performance index was independently associated with a higher risk of MACE in patients with atrial fibrillation (adjusted HR 1.12; 95% CI 1.01-1.25; P=0.038).