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G protein coupled receptor kinases play a crucial role in the pathogenesis of neurocardiovascular diseases such as heart failure and hypertension, offering potential novel therapeutic targets.
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The review highlights the pathophysiological role of GRKs, particularly GRK-2, in cardiovascular diseases like heart failure and hypertension, suggesting potential as a biomarker and therapeutic target.
In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of β-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of post-ischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of β-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directins for scientific research.
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Bojić et al. (2012) conducted a review in Neurocardiovascular diseases (coronary artery disease, heart failure, hypertension). G protein coupled receptor kinases (GRKs) was evaluated. G protein coupled receptor kinases play a crucial role in the pathogenesis of neurocardiovascular diseases such as heart failure and hypertension, offering potential novel therapeutic targets.
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