Key result
G protein-coupled receptor kinase-2 (GRK2) is upregulated in heart failure and influences cardiac contractile function, cell metabolism, and survival.
Design
Review
Authors
Loading...
GRK2 upregulation may link contractility, metabolism, and survival in HF; leaves open its viability as a therapeutic target.
GRK2 may serve as a nodal link in myocytes, influencing cardiac contractile function, cell metabolism, and survival, contributing to heart failure independent of its canonical role.
Woodall et al. (2014) conducted a review in Heart failure. G Protein-Coupled Receptor Kinase 2 (GRK2) was evaluated. G protein-coupled receptor kinase-2 (GRK2) is upregulated in heart failure and influences cardiac contractile function, cell metabolism, and survival.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: