What is the clinical evidence from this study?

Study design: Cohort. Population: No pre-existing carotid atherosclerosis (n=2610). Intervention: Monocyte count vs. Lowest monocyte quartile. Primary outcome: Novel plaque formation (OR 1.85, 95% CI 1.41 to 2.43).

What question did this study set out to answer?

To determine if monocyte count is a predictor of future plaque formation in individuals without pre-existing carotid atherosclerosis.

March 4, 2005StrokeOpen Access

Monocyte Count Is a Predictor of Novel Plaque Formation

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Key result

Higher monocyte count independently predicted novel carotid plaque formation over 7 years, with the highest quartile having an increased risk compared to the lowest (OR 1.85; 95% CI 1.41-2.43).

Why the study?

Does higher monocyte count predict novel plaque formation in persons without pre-existing carotid atherosclerosis?

Key Points

To determine if monocyte count is a predictor of future plaque formation in individuals without pre-existing carotid atherosclerosis.
Measured monocyte count, white cell count, fibrinogen, intima-media thickness, and cardiovascular risk factors in 2610 participants aged 25 to 82.
Followed participants for 7 years and assessed new plaque formation via ultrasound screening.
Conducted multivariate analysis controlling for age, sex, cholesterol, smoking, blood pressure, and intima-media thickness.
For every 1 standard deviation increase in monocyte count, the risk of higher plaque category increased by 18% (OR 1.18, 95% CI 1.08 to 1.29).
The risk for having plaque was 1.85 times greater in the highest monocyte quartile compared to the lowest (OR 1.85, 95% CI 1.41 to 2.43).
No significant association was found between plaque formation and white cell count or fibrinogen.

Study Design

Type

Cohort (n=2,610)

Structured PICO

Does higher monocyte count predict novel plaque formation in persons without pre-existing carotid atherosclerosis?

Population

2,610 men and women aged 25 to 82 years without pre-existing carotid plaque, followed for 7 years.

Exposure

Higher monocyte count in blood

Comparator

Lower monocyte count (e.g., lowest quartile)

Outcome

Number of novel plaques (grouped as none, 1 plaque, and 2 or more plaques) on ultrasoundsurrogate

Main Result

Odds Ratio: 1.85 (95% CI 1.41–2.43)

Monocyte count is an independent predictor of future carotid plaque formation in individuals without pre-existing atherosclerosis, suggesting a role for monocyte activity in early atherogenesis.

Discussion

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Implication

Monocyte count was associated with incident carotid plaques; leaves open its added value for risk stratification.

Cite This Study

Johnsen et al. (2005) conducted a cohort in No pre-existing carotid atherosclerosis (n=2,610). Monocyte count vs. Lowest monocyte quartile was evaluated on Novel plaque formation (OR 1.85, 95% CI 1.41 to 2.43). Higher monocyte count independently predicted novel carotid plaque formation over 7 years, with the highest quartile having an increased risk compared to the lowest (OR 1.85; 95% CI 1.41-2.43).

synapsesocial.com/papers/6a653d43f57138304a40ed9b https://doi.org/10.1161/01.str.0000158909.07634.83

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Monocyte Count Is a Predictor of Novel Plaque Formation

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Monocyte Count Is a Predictor of Novel Plaque Formation

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider