Higher monocyte count was independently associated with subclinical carotid plaque formation in a healthy community population (OR per SD increase 1.4; 95% CI 1.13-1.73; P=0.002).
Cross-Sectional (n=1,111)
Is monocyte count an independent risk marker for subclinical carotid atherosclerosis in a healthy community population?
Monocyte count may serve as an inexpensive, independent risk marker for subclinical carotid atherosclerosis, outperforming other inflammatory markers like hs-CRP and IL-6.
Odds Ratio: 1.4 (95% CI 1.13–1.73)
p-value: p=0.002
BACKGROUND AND PURPOSE: Systemic inflammatory markers have been shown to predict future cardiovascular events, but whether they are associated with early atherosclerosis is uncertain. We investigated the relationship of inflammatory markers interleukin-6 (IL-6), high-sensitive C-reactive protein (hs-CRP), fibrinogen, monocyte count, and white cell count (WCC) with subclinical carotid atherosclerosis in a healthy community population. METHODS: B-mode carotid ultrasound was performed on 1111 randomly selected male and female subjects aged 27 to 77 years. Serum IL-6, hs-CRP, plasma fibrinogen, monocyte count, and WCC were measured on all subjects, along with conventional cardiovascular risk factors. RESULTS: Multivariate analysis showed that IL-6 (P53 years; P=0.003). CONCLUSIONS: In a healthy community population, monocyte count is a better independent predictor of common carotid IMT and plaque formation than IL-6, hs-CRP, fibrinogen, and WCC. Monocyte count may represent an inexpensive, easy-to-measure risk marker for subclinical carotid atherosclerosis.
Chapman et al. (Tue,) conducted a cross-sectional in Subclinical carotid atherosclerosis (n=1,111). Monocyte count was evaluated on Carotid plaque formation (OR 1.4, 95% CI 1.13-1.73, p=0.002). Higher monocyte count was independently associated with subclinical carotid plaque formation in a healthy community population (OR per SD increase 1.4; 95% CI 1.13-1.73; P=0.002).